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. 2020 Jun 16;11:661. doi: 10.3389/fphys.2020.00661

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Copyright © 2020 Fan and Kassiri.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mature human TIMP3 protein sequence and putative binding sites (domain) of TIMP3 with its interactors. hI-II, sA-F, location and extent of α-helices and β-strands as described (Wisniewska et al., 2008). Asn121 separates the N- and C-terminal domains of TIMP3. Partners of N-terminal TIMP3: ADAM17 (a disintegrin and metalloproteinase 17, *), ADAM12, MMPs (matrix metalloproteinases), ADAMTS (ADAM with thrombospondin motifs)-2, -4, -5, AT2R (angiotensin II type 2 receptor), GAGs (glycosaminoglycans, ⇑); LRP-1 [Low-density lipoprotein (LDL) receptor-related protein-1, ♢]. Partners of C-terminal TIMP3: MMP-2, -3, proMMP-2, -9, GAGs (⇑), fibulin-3, PC5A (a soluble isoform of proprotein convertase 5), VEGFR2 (vascular endothelial growth factor receptor 2).