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Role of TIMP3 in cardiovascular pathologies. TIMP3 deficiency (TIMP3– /–) exacerbates the structure change and dysfunction of the heart and/or the artery in a variety of animal models. AAA, abdominal aortic aneurysm; Ang II, Angiotensin II; ApoE– /–, apolipoprotein E-deficient mice; DCM, dilated cardiomyopathy; LV, left ventricular; MI, myocardial infarction.
