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(A) The mRNA and protein expression levels of SIRT1. Data represent mean ± SD. **P<0.01 compared with si-con. (B–E) Expression of collagen II, aggrecan, MMP13 and ADAMTS4. (F) Expression of collagen II, aggrecan, MMP13 and ADAMTS4 proteins. Data represented mean ± SD. Compared with the con group, **P<0.01, compared with the si-SIRT1 group. ##P<0.01, compared with the miR-122 inhibitor group. con means control.
