Skip to main content
. 2020 Jun 17;16:1320–1334. doi: 10.3762/bjoc.16.113

Table 5.

Preparation of derivatives 22ae by formylation of octahydropyrrolo[3,4-e]indole-1,3-diones 9.a

graphic file with name Beilstein_J_Org_Chem-16-1320-i003.jpg

entry 9 R1 R2 T (°C) t (h) 22 (%)b

1 9f CN Bn 40 1 22a (95)
2 9h CO2Me CH2C6H4-2-Br 0 3 22b (88)
3 9l CO2Me CH2C6H2-2-Br-4,5-(OMe)2 0 2 22c (89)
4 9o CO2Me allyl 25 2 22d (84)
5 9p CO2Me propargyl 25 2 22e (80)

aReagents: 9 (1.0 mol equiv), POCl3 (1.2 mol equiv) and DMF (1.2 mol equiv). bAfter purification by column chromatography.