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. 2020 Jun 16;11:506. doi: 10.3389/fphys.2020.00506

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Copyright © 2020 Noiret, Puch, Riffaud, Costantini, Riou, Aujard and Terrien.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Levels of (A) mitochondrial oxidative coupling rate (% of baseline OCR), (B) Mitochondrial reserve capacity (% of baseline OCR), (C) Glycolytic Potential (% of baseline ECAR), and (D) Mt/Nu DNA ratios measured in cultured fibroblasts from female (F) and male (M) mouse lemurs before (CTL, light gray) and after (60% CR, dark gray) a 2-week exposure to a 60% caloric restriction. Boxes indicate least square means and error bars represent the 95% confidence interval, except for GlcP (median and total range). Significant differences within sex groups (effect of CR, lower bars) and between sex groups (effect of sex, upper bars) are represented, as well as the significance of the interaction of Sex*Diet (CTL or CR). *< 0.05; ° < 0.1.