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. 2020 Jun 16;11:506. doi: 10.3389/fphys.2020.00506

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Copyright © 2020 Noiret, Puch, Riffaud, Costantini, Riou, Aujard and Terrien.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Graphic representation of the cellular metabolic potential measured in cultured fibroblasts from female (circles) and male (triangles) mouse lemurs before (CTL, white) and after (60% CR, gray) a 2-week exposure to a 60% caloric restriction. Metabolic Potentials (mean + sd) are represented by dashed lines between two cell energy phenotypes: “Basal OCR/ECAR” (sd in solid lines) and “Stressed OCR/ECAR” (sd in dashed lines; determined under FCCP conditions, chemically mimicking an induced energy demand). The 2-dimension description of the metabolic potential informs on the general capacity of the cells to meet an energy demand either by glycolysis (“Glycolytic” phenotype), oxidative respiration (“Oxydative” phenotype) or both (“Energetic” phenotype).