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. 2020 Jun 23;88:102063. doi: 10.1016/j.ctrv.2020.102063

Table 2C.

Pharmacokinetic interactions related to hydroxychloroquine, azithromycin and remdesivir.

graphic file with name fx8_lrg.gif

Inline graphic: No data available or degree of interaction not measurable.

Inline graphic: 1 < AUC ratio ≤ 1.4 (DDI Predictor), No interaction expected (Drugs Information Database, HIV Drugs Interaction, Theriaque).

Inline graphic: Potential Weak Interaction (HIV Drug Interaction), Minor Interaction (Drugs Information Database), To be taken into account or precaution for use (Theriaque), 1.5 ≤ AUC ratio ≤ 1.9 (DDI Predictor).

Inline graphic: Potential Interaction (HIV Drug Interaction), Moderate Interaction (Drugs Information Database), Avoid association (Theriaque), 2 ≤ AUC Ratio ≤ 9.9 (DDI) or 0.4 < AUC Ratio AUC < 0.6 (DDI Predictor).

AUC Ratio = area under the substrate concentration in blood or plasma over the dosing interval at a steady-state/AUC of the substrate given with an inhibitor an inducer.

▲ Increase of lopinavir/ritonavir concentration.

▾ Decrease of lopinavir/ritonavir concentration.