Table 1.
Summary of clinical and laboratory parameters recorded from a cohort of 115 adults with HBV infection in Cape Town, South Africa, comparing groups with HBV monoinfection (n=76) versus HIV/HBV coinfection (n=39). For extended version of table, see Suppl data table 3.
| Whole Cohort | HBV monoinfection | HIV/HBV coinfection | p-valuea | |
|---|---|---|---|---|
| Sex M:F (% male) | 65:50 (57%) | 46:30 (61%) | 19:20 (49%) | 0.24 |
| Median age in years at enrollmentb (IQR) | 44 (36-53) | 45 (35-54) | 41 (37-50) | 0.51 |
| Median body weight in kgc (IQR) | 73 (60-84) | 75 (60-86) | 71 (60-80) | 0.23 |
| Proportion HBeAg positived (%) | 22/107 (21%) | 9/70 (13%) | 13/37 (35%) | 0.011 |
| Proportion with elevated ALT above ULNe (%) | 52/113 (46%) | 36/74 (49%) | 16/39 (41%) | 0.55 |
| Proportion with elevated AST above ULNf (%) | 31/95 (33%) | 20/58 (35%) | 11/37 (30%) | 0.66 |
| Median BRg, mmol/L (IQR) | 7 (5-14) | 9 (6-17) | 5 (4-9) | 0.004 |
| Proportion with elevated BR > ULNg (%) | 19/109 (17%) | 16/70 (23%) | 3/39 (8%) | 0.06 |
| Median platelet counth, x103 / µl (IQR) | 236 (163-297) | 227 (156-294) | 240 (170-307) | 0.41 |
| Proportion with thrombocytopaeniah (%) | 11/106 (10%) | 11/67 (16%) | 0/39 (0%) | 0.007 |
| Proportion with APRI score >2 | 8/92 (9%) | 8/55 (15%) | 0/37 (0%) | 0.02 |
| Proportion with FIB-4 score >3.25 | 21/92 (23%) | 16/55 (29%) | 5/37 (14%) | 0.13 |
| Proportion assessed by elastographyi (%) | 48/115 (42%) | 13/76 (17%) | 35/39 (90%) | <0.0001* |
| Median elastography score, kPa (IQR) | 6.1 (4.8-9.0) | 7.8 (5.4-10.3) | 5.8 (4.5-8.2) | 0.15 |
| Proportion with elastography score >9kPa (%) | 12/48 (25%) | 5/13 (38%) | 7/35 (20%) | 0.26 |
| Proportion with hepatic complicationsj (%) | 20/112 (16%) | 15/73 (21%) | 5/39 (13%) | 0.12 |
| Proportion with CKD stage II or IIIk | 16/111 (14%) | 9/72 (13%) | 7/39 (18%) | 0.79 |
IQR = inter-quartile range; ALT = alanine transferase; ULN = upper limit of normal.
p-value for categorical variables by Fisher's Exact Test, and for continuous variables by Mann Whitney test.
Age available for 115 individuals.
Body weight available for 111/115 individuals.
HBeAg status available for 107/115 individuals.
ALT available for 113/115 individuals, with ULN defined as 19 iu/ml for females and 30 iu/ml for males.
AST available for 95/115 individuals, with ULN defined as 40 iu/ml.
BR available for 109/115 individuals; ULN defined as 17 mmol/L.
Platelet count available for 106/115 individuals; moderate/severe thrombocytopaenia defined as platelet count <75 × 103 / ul 27.
Elastography data available for 50/119 individuals.
Hepatic complications reviewed for 108/112 individuals, defined as a documented diagnosis of HCC and/or cirrhosis.
CKD (chronic kidney disease) stages II and III defined as eGFR <90 ml/min/1.73m2.
also significant on multivariate analysis.