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. 2020 Jun 16;9:F1000 Faculty Rev-612. [Version 1] doi: 10.12688/f1000research.24748.1

Figure 2. Necroptosis pathway in Stevens-Johnson syndrome/toxic epidermal necrolysis.

Figure 2.

Drug-stimulated monocytes secrete annexin A1. Annexin A1 binds to FPR1, RIP1 and RIP3 form the necrosome, and MLKL is phosphorylated by RIP3. Phosphorylated MLKL translocates to the plasma membrane and induces cell death. FPR1, formyl peptide receptor 1; MLKL, mixed lineage kinase domain-like; RIP1, receptor interacting kinase 1.