Figure 1.

An overview of the workflow for the development and evaluation of the proposed dynamic reaction picklist. The source data were the allergy entries in an allergy repository of a large Massachusetts healthcare system containing allergens and reactions. The data preparation processes include (1) allergen consolidation conducted through knowledge-based mapping, (2) refinement of reaction picklist conducted through exclusive manual expert review, and (3) reaction reconciliation from free-text entries using natural language processing. The dynamic reaction picklist was then developed using association rule-mining measures and evaluated.