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. 2020 May 17;27(6):917–923. doi: 10.1093/jamia/ocaa042

Table 3.

Top 15 most common reactions for Amoxicillin and Ibuprofen using 3 association measures

Rank Top 15 most common reactions for Amoxicillin
Top 15 most common reactions for Ibuprofen
Support Lift’ Tfidf’ Support Lift’ Tfidf’
1 Rash Rash Rash GI upset GI upset GI upset
2 Hives Hives Hives Hives Hives Hives
3 GI upset Diarrhea GI upset Rash Swelling Swelling
4 N/V GI Upset Diarrhea Swelling GI Hemorrhage Rash
5 Itching Itching N/V N/V Bleeding N/V
6 Diarrhea N/V Itching Anaphylaxis Facial swelling GI Hemorrhage
7 Swelling Maculopapular rash Swelling Itching Rash Angioedema
8 Anaphylaxis Vaginitis Anaphylaxis Angioedema Angioedema Anaphylaxis
9 SOB Swelling Vaginitis SOB Gastritis Bleeding
10 Angioedema Erythema multiforme Maculopapular rash GI Hemorrhage Ulcer Itching
11 Vaginitis Anaphylaxis Angioedema Bronchospasm Peptic ulcer Facial swelling
12 Fever Rash w/ joint painsa SOB Facial swelling Eye swelling SOB
13 Maculopapular rash SOB Fever Bleeding Renal toxicity Renal toxicity
14 Erythema Morbilliform rash Rash w/ joint painsa Wheezing N/V Bronchospasm
15 Facial swelling Angioedema Erythema multiforme Lip swelling Lip swelling Wheezing

Abbreviations: GI hemorrhage, gastrointestinal hemorrhage; N/V, nausea and/or vomiting; SOB, shortness of breath.

a

Rash w/joint pains (serum sickness).