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. Author manuscript; available in PMC: 2021 Jan 1.
Published in final edited form as: Biochem Pharmacol. 2019 Nov 21;171:113728. doi: 10.1016/j.bcp.2019.113728

Figure 6: JNK inhibition blocks superoxide production induced by X1 and sorafenib.

Figure 6:

Huh7 cells incubated in HBSS were loaded with MitoSOX Red, as described in MATERIAL &METHODS. Images were collected after addition of vehicle (Untreated), X1 (10 μM) and sorafenib (3.5 μM), for 1 h and 30 min, respectively, in absence (upper panels) and presence (lower panels) of SP600125 (30 μM) or JNK inhibitor VIII (5 μM) added 1 h before X1 or sorafenib. In B, MitoSOX Red relative fluorescence was quantified after treatments as compared to vehicle. *p<0.05 vs vehicle, #p<0.05 vs X1, §p<0.05 vs sorafenib from 3 independent experiments.