Table 1.

Binding energy values of fungal metabolites 1–25 against five SARS-CoV2 proteins.

Compound	Viral Target	Binding Energy (kcal/mol)
		PLpro	3CLpro	RdRp	nsp15	S Protein
Altertoxin V (1)	HIV	−9.4	−7.2	−8.5	−8.1	−7.1
Altertoxin II (2)	HIV	−9.2	−7.5	−8.3	−7.6	−7.6
Penicillixanthone A (3)	HIV	−9.5	−8.2	−8.1	−6.9	−8.1
Cytochalasin Z8 (4)	HIV	−10.3	−7.9	−9.6	−8.5	−8.1
Stachybotrosin D (5)	HIV	−9.5	−6.5	−7.8	−7.8	−7.1
Chloropupukeanolide A (6)	HIV	−10.0	−7.5	−7.7	−6.8	−8.1
Phomasetin (7)	HIV-1 Integrase	−9.6	−7.2	−6.9	−6.9	−8.3
Isochaetochromin D1 (8)	HIV-1 Integrase	−9.9	−7.9	−8.4	−9.1	−9.5
Aspergilol H (R) (9)	Herpes simplex	−9.6	−7.9	−7.6	−8.2	−9.1
Aspergilol H (S) (10)	Herpes simplex	−9.2	−8.3	−7.7	−8.1	−9.2
11a-Dehydroxyiso- terreulactone A (11)	Herpes simplex	−8.9	−8.9	−9.1	−8.4	−10.2
Arisugacin A (12)	Herpes simplex	−10.0	−8.0	−8.5	−8.5	−9.2
Aspernolide A (13)	Herpes simplex	−9.2	−7.1	−7.5	−7.5	−9.3
Rhodatin (14)	Hepatitis C	−9.0	−7.1	−7.9	−7.9	−9.9
Scedapin C (15)	Hepatitis	−10.9	−8.6	−9.2	−8.9	−9.4
Scequinadoline A (16)	Hepatitis C	−9.1	−8.7	−9.1	−7.9	−8.5
14S-Oxoglyantrypine (17)	Influenza	−9.6	−8.4	−8.3	−7.4	−7.6
Deoxynortryptoquivaline (18)	Influenza	−9.6	−7.6	−7.4	−7.1	−8.0
Quinadoline B (19)	Influenza	−10.6	−8.3	−9.8	−9.1	−10.5
Norquinadoline A (20)	Influenza	−10.9	−8.1	−8.5	−8.6	−8.3
Asperterrestide A (S) (21)	Influenza	−8.9	−8.3	−7.6	−7.3	−8.7
Asperterrestide A (R) (22)	Influenza	−8.9	−8.4	−7.6	−7.4	−9.7
Rubrolide S (23)	Influenza	−8.7	−7.7	−7.4	−7.8	−10.3
Isoaspulvinone (24)	Influenza	−7.7	−7.4	−7.1	−8.6	−9.7
Pulvic acid (25)	Influenza	−7.9	−6.6	−7.5	−8.5	−9.3