Table 3.

Lipinski’s Rule of Five for ADME analysis of compounds 1–25.

Compound	MW (<500)	#H acceptors (<10)	#H-bond donors (<5)	Lipophilicity MLogP (<5)	Lipinski #violations	Drug Likeness
1	318.32	4	1	1.58	0	yes
2	350.32	6	3	0.47	0	yes
3	638.57	14	6	−1.36	3	no
4	465.58	5	3	2.83	0	yes
5	428.56	5	2	2.89	0	yes
6	643.08	11	2	2.09	2	no
7	413.55	4	2	2.39	0	yes
8	544.51	10	6	0.48	2	no
9	598.6	10	6	1.26	2	no
10	598.6	10	6	1.26	2	no
11	468.54	7	1	2.78	0	yes
12	496.55	8	2	1.57	0	yes
13	424.44	7	2	2.09	0	yes
14	398.45	6	3	1.69	0	yes
15	564.61	9	1	0.97	2	no
16	487.55	6	3	1.63	0	yes
17	358.35	4	2	1.84	0	yes
18	516.55	8	1	2.61	1	yes
19	439.47	5	1	2.00	0	yes
20	471.51	6	3	1.36	0	yes
21	480.56	5	4	0.86	0	yes
22	480.56	5	4	0.86	0	yes
23	348.39	4	1	3.29	0	yes
24	296.27	5	3	1.32	0	yes
25	308.28	5	2	1.76	0	yes