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RUNX3 inhibits TEAD/YAP-mediated gene transcription.
Under conditions of high RUNX3 (left panel) DNA-binding ability of TEAD is inhibited and transcription of TEAD/YAP target genes (e.g., CTGF and CYR61) is attenuated. When RUNX3 is inactivated or expressed at relatively low levels (right panel) TEAD/YAP drives transcription of oncogenic target genes.
