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. Author manuscript; available in PMC: 2021 May 13.
Published in final edited form as: Cell Host Microbe. 2020 May 13;27(5):710–724.e7. doi: 10.1016/j.chom.2020.04.007

Figure 6. Six distinct neutralizing epitopes defined by panel of 15 DENV3 hmAbs.

Figure 6.

We identified six distinct functional type specific neutralizing epitopes in DENV3. A) Summary of antibody properties, phenotypes and interaction sites using GOF DENV1/3 or LOF DENV3/1 chimeras, DENV3 genotype variants and DENV3 genotype chimeras.

B) Shown is a ribbon diagram of a DENV3 E trimer with EDI in red, EDII in yellow and EDIII in blue. Predicted functional epitope sites are shown as black circles. hmAbs in Group 1a interface with EDI differently from Group 1b, while Group 1c interacts in a more complex manner. The epitope for DENV-144 has the highest degree of uncertainty. HmAbs from secondary DENV3 infection are in purple squares.