Figure 2.

Distribution of critical value for the different methods under the set up: Drug A and Drug B both have one active dose group with sample size per dose group=25. The first effect size (δ₁) is 0 and the second effect size (δ₂) varies. Note that $T_{11}^2$ is addressed as $T_{11}^B$ in the article and the plots are shown in terms of the non-centrality parameter of test statistics $T_{11}^2$, i.e. ${\delta }_{211}={\delta }_2/\sqrt{2/25}$, which is the second effect size scaled by the harmonic sum of sample size of the dose combination and the second monotherapy. (a) Boxplot distribution at δ₂₁₁ = 0.707; (b) boxplot distribution at δ₂₁₁ = 1.591; (c) boxplot distribution at δ₂₁₁ = 3.359; (d) boxplot distribution at δ₂₁₁ = 5.127.