Figure 7:

Diagram of PCR biomarkers

The diagram shows graphical representation of biomarkers for cyto-protective genes (A, B, C), for ECM markers (D) and proliferation markers (E). EGR gene family encodes for TF that bind as zinc finger proteins to DNA. ATF dimer is formed by 2 ATF or ATF and JUN proteins that belong to bZIP family of TF. Genes FOSB and/or JUNB and/or JUND together form an AP1 dimer (activator protein 1) which serves as a TF that regulates gene expression by binding to DNA by bZIP domain. COL1A1 gene encodes for alfa 1 subunit of collagen 1 and together with alfa 2 subunit (COL1A2 gene) they form procollagen 1 molecule. A collagen fiber is made from triple-stranded pro-collagen molecules, multiple fibers form the ECM. HIST2H4 is S phase marker (DNA replication) of the cell cycle and CCNB2 is M phase (mitosis) marker.

ECM=Extracellular matrix, DBD=DNA-binding domain, bZIP (leucine zipper), TF=transcription factor