Skip to main content
. 2020 Jun 16;14:569. doi: 10.3389/fnins.2020.00569

FIGURE 2.

FIGURE 2

Summary of the effects of specific polydrug combinations on assays of addiction-like behaviors. Studies are organized into X/Y polydrug combos (columns) and behavioral assays (rows), with subcolumns for the effect of drug Y on drug X (left subcolumn) and the effect of drug X on drug Y (right subcolumn). Symbols represent the net effect of the X/Y polydrug combo on a given behavior, with color depicting the specific drugs tested. Sensitization: locomotor sensitization; Conditioned place preference: acquisition, expression; Drug intake: self-administration; Motivation: progressive ratio, behavioral economics; Drug craving: reinstatement, cue reactivity. Data from Mello and Mendelson (1978), Mello et al. (1980), Mello et al. (2014), Huston-Lyons et al. (1993), Foltin et al. (1993), Aspen and Winger (1997), Ranaldi and Wise (2000), Valverde et al. (2001); De Vries et al. (2001), Parker et al. (2004); Solinas et al. (2005), Liang et al. (2006); Biala and Budzynska (2006), Ward et al. (2006); Panlilio et al. (2007), Panlilio et al. (2013), Winger et al. (2007), Lê et al. (2010), Lê et al. (2014), Levine et al. (2011), Cortright et al. (2011), Pomfrey et al. (2015), Maguire and France (2016); Mahmud et al. (2017), Fredriksson et al. (2017); Giasson-Gariépy et al. (2017), Griffin et al. (2017); Schwartz et al. (2018), Winkler et al. (2018); Manwell et al. (2019), Ponzoni et al. (2019), Crummy et al. (2020), and Stennett et al. (2020).