Figure 7.

Mice deficient in ILC2s produce less peanut-specific IgE antibodies. A. Naïve Rora^fl/flIl7r-Cre mice or Rora^fl/fl littermate control mice were i.n. exposed to peanut flour or PBS twice, one week apart. Four weeks later, plasma was assessed for peanut-specific Igs. B. Day 34 blood antibody titers for peanut-specific IgE, IgG1, IgG2a, and IgG2b from mice described in Fig. 7A. Error bars represent mean ± SEM. Data are presented as a pool from two independent experiments, a total of 6–9 mice in each group. *P<0.05 and **P<0.01 compared to Rora^fl/flIl7r-Cre mice exposed to peanut flour.