Table 1. Distribution of the Improvement Outcome (Symptom Score at Week 8 Minus Symptom Score at Baseline) on Each of 21 Symptoms on the HRSD-21 Report in the Data Set Set.
| Item | Symptom | Magnitude of treatment-related symptom improvement, mean (SD)a |
|---|---|---|
| 1 | Depressed mood | −1.53 (0.95) |
| 2 | Self-critical | −1.12 (1.03) |
| 3 | Suicidal thoughts | −0.44 (0.71) |
| 4 | Trouble sleeping | −0.67 (0.87) |
| 5 | Nighttime awakening | −0.63 (0.90) |
| 6 | Waking early | −0.58 (0.91) |
| 7 | Loss of interest | −1.57 (1.11) |
| 8 | Psychomotor retardation | −0.62 (0.75) |
| 9 | Agitation | −0.69 (0.91) |
| 10 | Worrying | −1.14 (0.99) |
| 11 | Physical anxiety | −0.72 (0.92) |
| 12 | Appetite changes | −0.46 (0.79) |
| 13 | Energy loss | −0.89 (0.75) |
| 14 | Libido loss | −0.49 (0.86) |
| 15 | Health preoccupation | −0.19 (0.58) |
| 16 | Weight loss | −0.31 (0.71) |
| 17 | Loss of insight | −0.08 (0.32) |
| 18 | Diurnal variation | −0.38 (0.82) |
| 19 | Unreality and nihilism | −0.26 (0.70) |
| 20 | Paranoia | −0.16 (0.52) |
| 21 | Obsessive thoughts | −0.09 (0.43) |
Abbreviation: HRSD-21, 21-Item Hamilton Rating Scale for Depression.
a
Negative values for mean magnitude change are indicative of improvement in symptoms.