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The summary of DYRK1A in regulating Mcl-1 and anti-NSCLC effects of Bcl-2 inhibitors. DYRK1A promotes the stability of Mcl-1, and genetic or pharmacological inhibition of DYRK1A promotes the proteasome-dependent degradation of Mcl-1 in NSCLC cells. Mcl-1 overexpression confers acquired resistance to Bcl-2 inhibitors in NSCLC. Thus, DYRK1A suppression sensitizes NSCLC cells to Bcl-2 inhibitors treatment via regulating Mcl-1.
