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Comparison of the molecular effects of different LSD1 inhibitors.
| EPI-111 | Phenelzine sulfate | ORYZON | GSK | |
|---|---|---|---|---|
| FAD activity |  |
 |
|
|
| LSD1 nuclear pool specific (serine 111p) |  |
|
 |
|
| Blocks LDS1:importin alpha 1 & 3 | |
|
|
|
| Targets NLS (phosphorylated at serine 111) | |
|
|
|
| LSD1:CoREST destabilization | |
|
|
|
