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. Author manuscript; available in PMC: 2020 Oct 3.
Published in final edited form as: Nat Struct Mol Biol. 2019 Oct 3;26(10):955–962. doi: 10.1038/s41594-019-0305-z

Fig. 3 |. CysBD is the keystone of Polδ assembly.

Fig. 3 |

a, Simultaneous interactions of CysBD with the regulatory and catalytic modules (in yellow and red respectively and dotted surface) nucleates the assembly of Polδ. CysBD amino acids tested previously in genetic experiments for interactions and those identified from our structure are labeled. b, Potential contacts between the regulatory and catalytic modules are mapped on the schematic and listed in the legend below. c, Human Polδ disease mutations R506H, R507C and I1070N corresponding to R511, R512 and L1068 mapped on a schematic of the structure of yeast Polδ. These mutations localize at the interface between the catalytic and regulatory modules.