Figure 2. Dendritic spiking is deteriorated in the in vivo-like context.

Currentscape plots ⁶⁷ are shown above the shape plots in A (cell 1) and B (cell 2). The dots in the shape plots indicate the recording sites (S = Soma; D1–D4 = Dendrite 1–4). All recording sites were chosen such that they are along the same dendritic path. In each currentscape plot, the top trace is the voltage trace (y-axis scale bar = -50 mV [horizontal dashed line] to -20 mV), the filled-in black traces above and below the coloured plots are the total outward and inward currents respectively (dotted lines = ±0.5 pA, ±5 pA, ±50 pA), and the coloured plots show the percent contributions of each individual outward (top half of the plot) and inward (bottom half of the plot) current (see colour references in the legend on the right) to the total outward and inward currents. For each recording site location we show one in vitro currentscape plot (top) and one corresponding IVL currentscape plot (bottom), in the last second of simulation time (time axis = 9 s to 10 s). Distance values above each set of in vitro/IVL currentscape plots indicate the recording site distance from soma.