Figure 4. Mean Score Changes From Baseline to Month 18 for the Secondary (Device 1) Cohort .

The model used time as a categorical variable and included fixed effects for the treatment, the treatment-by-time interactions, baseline outcome, sex, age, baseline score on the Mini-Mental State Examination, and apolipoprotein E ε4 allele carriage status. The shaded region indicates the open-label phase. Error bars indicate 95% CIs.