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CC‐5013 inhibited HMGB1 and pyroptosis in the ALF and AKI mouse model. A‐C, Serum levels of HMGB1, IL‐1β, IL‐18, ALT, AST and TBil were determined in different groups. D‐E, Protein levels of IL‐1β, IL‐18, NLRP3, p10 + p12 and GSDMD in liver and kidney tissues were detected by Western blotting in different groups. Data are shown as mean ± SD. n = 10. # P < .05, compared with the normal group. *P < .05, compared with the LPS/D‐Gal group
