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Inhibition of eIF2α activity prevents autophagosome recruitment to the PV. (A) C. burnetii-infected THP-1 cells in the presence or absence of ISRIB (10 μM) were processed for microscopy using antibodies against LC3 (red) and CD63 (green), and DAPI stained bacterial and host DNA (blue). (B) PV areas were measured from >50 cells. **, P < 0.01, and error bars indicate the standard deviations from the means. eIF2α activity was required for LC3 decoration of the PV membrane.
