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Typical features of chronic osteomyelitis. Initial inflammation and infection in the metaphysis lead to necrotic bone becoming a nidus for chronic infection, known as a sequestrum. In an attempt to control the infection, new bone mineralizes around the sequestrum and is termed the involucrum. Active infection results in the formation of a sinus to the outer periosteum where a periosteal abscess can develop. (Copyright Kenneth L. Urish.)
