FIG 5.
Comparison of live C. trachomatis yields between mice with or without deficiency in T-bet or RORγt following transcervical inoculation. Mice without (solid bars) or with deficiency in transcriptional factors T-bet (T-bet−/−; open bars) or RORγt (RORγt−/−; hatched bars) were infected with 5 × 106 IFU of C. trachomatis serovar D organisms via transcervical inoculation and then monitored for live-organism recovery from both swabs and genital tract tissues, including vagina (Vag), cervix (Cex), uterine/uterine horn (UH), and oviduct/ovary (OV). All swabs and tissues were harvested on day 3 after inoculation. The number of live organisms recovered from each swab or tissue was expressed as log10 IFU, and group means and standard deviations are shown. n = 5 for each data point, and the data are from two independent experiments. *, P < 0.05, and **, P < 0.01, for comparison of the indicated gene-deficient group with the wild-type group (Wilcoxon rank sum test).