FIG 6.
Comparison of live C. trachomatis yields between mice with or without deficiency in IFN-γ or IL-22 following transcervical inoculation. Mice without (solid bars; n = 10) or with (open bars; IFN-γ−/−; n = 4) or IL-22 (hatched bars; IL-22−/−; n = 7) deficiency in IFN-γ were infected with 5 × 106 IFU of C. trachomatis serovar D organisms via transcervical inoculation and then monitored for live-organism recovery from both swabs and genital tract tissues, including vagina (Vag), cervix (Cex), uterus or uterine horn (UH), and oviduct/ovary (OV). All swabs and tissues were harvested on day 3 after inoculation. The number of live organisms recovered from each swab or tissue is expressed as log10 IFU, and group means and standard deviations are shown. Data are from two independent experiments. *, P < 0.05 (Wilcoxon rank sum test).