FIG 7.
Comparison of live C. trachomatis yields between adaptive immunity-deficient mice with or without depletion of IFN-γ following transcervical inoculation. Adaptive immunity-deficient mice without (Rag1−/− + Ctrl IgG; solid bars) or with (Rag1−/− + αIFN-γ; open bars) depletion of IFN-γ were infected with 5 × 106 IFU of C. trachomatis serovar D organisms via transcervical inoculation and then monitored for live-organism recovery from both swabs and genital tract tissues, including vagina (Vag), cervix (Cex), uterus or uterine horn (UH), and oviduct or ovary (OV). All swabs and tissues were harvested on day 3 after inoculation. The number of live organisms recovered from each swab or tissue is expressed as log10 IFU, and group means and standard deviations are shown. n = 4 for each data point, and data are from two independent experiments. *, P < 0.05 (Wilcoxon rank sum test).