FIG 8.
Comparison of live C. trachomatis yields between adaptive immunity-deficient mice with or without depletion of NK1.1+ cells following transcervical inoculation. Adaptive immunity-deficient mice without (Rag1−/− + Ctrl IgG; solid bars) or with (Rag1−/− + αNK1.1; open bars) depletion of NK1.1+ cells were infected with 5 × 106 IFU of C. trachomatis serovar D organisms via transcervical inoculation. The infected mice were then monitored for live-organism recovery (a) and IFN-γ production (b) from genital tract tissues, including vagina (Vag), cervix (Cex), uterus or uterine horn (UH), and oviduct or ovary (OV). All tissues were harvested on day 7 after inoculation. Group means and standard deviations for numbers of live organisms recovered from each tissue (expressed as log10 IFU) and IFN-γ measured from the same tissues are shown. n = 4 to 5 for each data point from two independent experiments. *, P < 0.05 (Wilcoxon rank sum test).