TABLE 2.
Histopathological evaluation of extirpated heart tissue from rats
| Finding | Mean histopathological score ± SE for: |
||||
|---|---|---|---|---|---|
| Injury A (n = 11) | Injury B (n = 11) | Injury C (n = 12) | No injury (n = 11) | No infection (n = 11) | |
| Interventricular septum/right ventricle | |||||
| Inflammatory cell infiltration | 0.91 ± 0.09 | 1.18 ± 0.12 | 0.92 ± 0.08 | 1.00 ± 0.00 | 1.27 ± 0.14 |
| Focal necrosis | 0.00 ± 0.00 | 0.09 ± 0.09 | 0.08 ± 0.08 | 0.18 ± 0.18 | 0.27 ± 0.14 |
| Focal fibrosis | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.08 ± 0.08 | 0.09 ± 0.09 | 0.18 ± 0.18 |
| Thrombus | 0.27 ± 0.27 | 0.18 ± 0.12 | 0.00 ± 0.00 | 0.27 ± 0.27 | 0.18 ± 0.18 |
| Right coronary artery | |||||
| Necrosis | 0.36 ± 0.36 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 |
| Thrombus | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.27 ± 0.27 |
| Aortic valve | |||||
| Necrosis | 0.27 ± 0.14 | 0.09 ± 0.09 | 0.00 ± 0.00 | 0.00 ± 0.00 | 0.00 ± 0.00 |
| Thickening | 0.09 ± 0.09 | 0.64 ± 0.28 | 0.17 ± 0.11 | 0.09 ± 0.09 | 0.73 ± 0.19 |
| Proliferation of endothelial cells | 0.36 ± 0.15 | 0.45 ± 0.21 | 0.00 ± 0.00 | 0.09 ± 0.09 | 0.09 ± 0.09 |
| Increased mononuclear cells | 0.36 ± 0.15 | 0.36 ± 0.15 | 0.08 ± 0.08 | 0.00 ± 0.00 | 0.36 ± 0.20 |
| Fibrosis | 0.00 ± 0.00 | 0.45 ± 0.21 | 0.33 ± 0.22 | 0.09 ± 0.09 | 0.64 ± 0.15 |