TABLE 2.

TCS in B. pseudomallei

System	Description	Reference(s)
virAG	Regulates T6SS; required for full virulence; activated by host glutathione within the cytosol	72–76
BPSL0127 and BPSL0128	Required for survival in macrophages and murine infection models	52
mrgRS	Potential temp-sensing mechanism; also regulates antibiotic resistance	79, 80
bprRS	Required for virulence in a murine model; significant cross talk with other signaling pathways	81
bfmR and BPSL2025	HK is upregulated during infection and required for virulence. RR is involved in biofilm formation by regulation of fimbriae chaperone-usher assembly genes; required for persistence in macrophages in vitro, but not required for virulence in murine models.	83–85
irlRS	Involved in heavy metal resistance, not required for virulence in macrophages or animal models	86
narXL	Regulates nitrate reductase system; required for nitrate inhibition of biofilm formation	87