. 2020 Jun 22;88(7):e00931-19. doi: 10.1128/IAI.00931-19

TABLE 1.

Two-component systems of GBS^e

TCS	Locus tag		Type	Sensory domain	Regulator family	Gene name(s)	Relevant citation(s)	Selected homolog(s) (reference)
TCS	2603 V/R	A909	Type	Sensory domain	Regulator family	Gene name(s)	Relevant citation(s)	Selected homolog(s) (reference)
1	SAG0123	SAK_0174	RR		OmpR	hssRS	57	hssRS_Saureus (55, 56)
1	SAG0124	SAK_0175	HK	IM		hssRS	57	hssRS_Saureus (55, 56)
2	SAG0182	SAK_0248	HK	IM				lytST_Smutans (99)
2	SAG0183	SAK_0249	RR		LytTR			lytST_Smutans (99)
3	SAG0310	SAK_0380	HK	IM
3	SAG0311^a	SAK_0381	RR		LuxR
4	SAG0321	SAK_0391	HK	IM		liaSR	79, 80, 82	liaSR_Spneumo (79), liaSR_Bsubtilis (80, 81)
4	SAG0322	SAK_0392^b	RR		LuxR	liaSR	79, 80, 82	liaSR_Spneumo (79), liaSR_Bsubtilis (80, 81)
5	SAG0393	SAK_0467	RR		OmpR	saeRS	66	saeRS_Saureus (reviewed in reference 100)
5	SAG0394	SAK_0468	HK	IM		saeRS	66	saeRS_Saureus (reviewed in reference 100)
6	SAG0616	SAK_0701	RR		OmpR	vncRS		vncRS_Spneumo (101)
6	SAG0617	SAK_0702	HK	EX		vncRS		vncRS_Spneumo (101)
7 (orphan)	SAG0712	SAK_0838	RR		OmpR
8	SAG0719	SAK_0845^b	RR		OmpR			walRK_Spyogenes (102), vicRK_Spneumo (103)
8	SAG0720	SAK_0846	HK	Unknown				walRK_Spyogenes (102), vicRK_Spneumo (103)
9	SAG0976	SAK_1071	RR		OmpR	bceRS, nsrRK	87, 88, 95	bceRS_Smutans (92), bceRS_Bsubtilis (94)
9	SAG0977	SAK_1072	HK	IM		bceRS, nsrRK	87, 88, 95	bceRS_Smutans (92), bceRS_Bsubtilis (94)
10	SAG0984	SAK_1079	HK	EX		ciaRH	96, 97	ciaRH_Smutans (104)
10	SAG0985	SAK_1080	RR		OmpR	ciaRH	96, 97	ciaRH_Smutans (104)
11	SAG1016	SAK_1111	RR		LytTR	ltdRS	58
11	SAG1017	SAK_1112	HK	IM		ltdRS	58
12	SAG1327	SAK_1358	HK	EX
12	SAG1328	SAK_1359	RR		OmpR
13	SAG1624	SAK_1638	HK	EX		covRS, csrRS	34, 35, 37, 38, 40, 105, 106	covRS_Spyogenes (reviewed in references 107, 108), covRS_Smutans (109 –111)
13	SAG1625	SAK_1639	RR		OmpR	covRS, csrRS	34, 35, 37, 38, 40, 105, 106
14	SAG1791	SAK_1813	HK	EX		dltRS	78	dlt operon (reviewed in reference 75)
14	SAG1792	SAK_1814	RR		OmpR	dltRS	78	dlt operon (reviewed in reference 75)
15	SAG1921	SAK_1880	HK			maeEK	112
15	SAG1922	SAK_1881	RR		Unknown	maeEK	112
16	SAG1946	SAK_1906	RR		Other	fspSR	22
16	SAG1947	SAK_1907	HK	EX		fspSR	22
17^c	SAG1956^a	SAK_1917	HK	IM		rgfAC	40, 62, 63, 65
17^c	SAG1957	SAK_1918^a	RR		LytTR	rgfAC	40, 62, 63, 65
18	SAG1960	SAK_1921	HK	EX
18	SAG1961	SAK_1922	RR		OmpR
19	SAG2054	SAK_1992	RR		OmpR
19	SAG2055	SAK_1993	HK	EX
20^c	SAG2122	SAK_2061	RR		OmpR
20^c	SAG2123	SAK_2062	HK	EX
21^c	SAG2127	SAK_2066	HK	IM
21^c	SAG2128	SAK_2067	RR		Other
22^c^,^d	absent	SAK_0188	HK	EX		bgrSR, sak188/sak189	47, 52, 53
22^c^,^d	absent	SAK_0189	RR		OmpR	bgrSR, sak188/sak189	47, 52, 53

Strains where truncations or mutations are present.

Predicted to be essential (Hooven et al. [113]).

Putative orthologs founds in <95% of strains analyzed by Faralla et al. (22).

TCS was initially characterized as a homolog of TCS-6 but is a separate system.

Table adapted from mBio (22).