Table 2.

Summary data of analysis datasets with respect to recurrent exacerbations and early discontinuations

	Dataset A	Dataset B	Dataset C	Dataset D	Dataset E
Number of patients available for analysis	1746	1072	1613	1218	2049
Number of mod/sev exacerbations	1186	949	655	1350	2179
Number of patients with R number of mod/sev exacerbations
R = 0	1086	537	1170	604	920
R = 1	376	286	301	265	554
R ≥ 2	284	249	142	349	575
Percentage of patients with ≥1 mod/sev exacerbation	37.8%	49.9%	27.5%	50.4%	55.1%
Max. number of mod/sev exacerbations	12	10	6	11	11
Mean number of mod/sev exacerbations per patient years at risk	0.816	1.051	0.917	1.284	1.293
Number of early treatment discontinuations	392	221	235	180	421
Percentage of early treatment discontinuations	22.5%	20.6%	14.6%	14.8%	20.5%
Percentage of early treatment discontinuations in original data	31%	30%	19%	24%	25%

mod moderate, sev severe