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. 2020 Jun 22;21:414. doi: 10.1186/s12864-020-06803-8

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Mapping the number of replication origins in T. cruzi genome. Peaks determination was obtained using the MFA-seq data based on the number of reads (fold change) along the genome of cells in replicative and non-replicative phases (ratio S/G2) (fold change - fc) or determined by using the MACS2 software. The Venn diagram shows the number of peaks detected on the two CL Brener haplotypes Esmeraldo-like (a) and Non-Esmeraldo-like (b), according to the type of analysis cited above. The intersection between them corresponds to the consensus of the peaks, which have been determined as origins of replication. The number of peaks detected in all analyses was compared with the size of each chromosome in Esmeraldo like (c) and in Non-Esmeraldo-like (d). A trendline was plotted to facilitate visualization. Values of R² are shown