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. 2020 Jun 22;15:133. doi: 10.1186/s11671-020-03348-3

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 10 — Changes in primary endpoint value, R3, before, after 4 weeks use, and after 8 weeks use of an ampoule containing polymeric micelles of oleanolic acid and the control during clinical trial. R3 value of test product use: 0.094 ± 0.023 before use, 0.093 ± 0.023 after 4 weeks use, 0.086 ± 0.020 after 8 weeks use. R3 value of control product: 0.087 ± 0.023 before use, 0.091 ± 0.025 after 4 weeks use, 0.095 ± 0.024 after 8 weeks use (A.U. for arbitrary unit). *¹The wrinkle analysis of R3 value decreased statistically significantly. *²The wrinkle analysis of R3 value increased statistically significantly