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. Author manuscript; available in PMC: 2020 Jun 23.
Published in final edited form as: Leuk Res. 2015 Apr 30;39(7):719–729. doi: 10.1016/j.leukres.2015.04.002

Figure 5. DCA augments ROS production in AML cell lines.

Figure 5.

MOLM-14, THP-1, and AML20 cells were first exposed to DCA at IC30 or vehicle control for 24 hours. Then the cells treated with vehicle, ATO (IC50) alone, DCA (IC30) alone or DCA(IC30)+ATO(IC50) combined for additional 24 and 48 hours. DCA caused negligible ROS over-production without priming (Veh-DCA), but ROS production was high in cases of priming (DCA-DCA and DCA-ATO) for 24 and 48 hours. Up to 4-fold increase in the ROS production was detected in leukemia cells after 24 hours of the DCA treatment when compared to vehicle control. Hence, it appears that the difference resides in the time of exposure to DCA. *P < 0.05, ns: non-significant.