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. 2020 Jun 22;20:440. doi: 10.1186/s12879-020-05174-5

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Histological sections and cerebrospinal fluid microscopy. Arrows indicate characteristic cryptococcal elements with the capsule appearing as an unstained clear halo. Endomyocardium with granulomas but with no evidence of cryptococci a and b, CSF finding of cryptococci c, thyroid tumour necrotic area with cryptococci but with no signs of cryptococci in the adjacent normal thyroid glandular tissue d, thyroid tumour necrosis and focal intact tumour tissue e, thyroid tumour with cryptococci and inflammatory infiltrate f, thyroid parenchyma without cryptococci except for within a blood vessel, note budding indicated by the arrowhead g, cryptococcal elements in epithelioid cell granulomas in the thyroid parenchyma h, cryptococcal elements in granulomas in a thyroid-adjacent lymph gland i. Staining types are cryptococcal ink, hematoxylin and eosin (HE), the fungal-specific Grocott’s methenamine silver (GMS) stain and Periodic acid–Schiff (PAS)