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. 2020 Jun 22;18:245. doi: 10.1186/s12967-020-02417-6

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — The characteristics of m5C peaks and the joint analysis of methylation and transcriptome. a Motif with minimum E-value of m5C in the hepatocellular carcinoma (HCC) group. b Motif with minimum E-value of m5C in the adjacent tissues group. These two motifs are only slightly different at the last base. c, d Pie chart of m5C peaks in different regions of mRNA. e The number of m5C peaks in HCC and adjacent tissues on each mRNA. Most mRNAs have only one methylation peak. f Scatter plot of the relationship between gene expression level and methylation level. The Y-axis and X-axis represent the expression levels of mRNAs in HCC and paired non-tumor tissues, red dots represent mRNAs with a high methylation level, blue dots represent low methylation horizontal mRNAs, and gray represents no significant difference