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. 2020 Jun 22;20:582. doi: 10.1186/s12885-020-07067-x

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — SOP enhances the effects of cisplatin in gastric cancer cells. a AGS cells and b SGC7901 cells were treated with 10 μM cisplatin alone or in combination with 3 μM SOP for indicated days and CCK-8 assay was used to determine cellular cytotoxicity. c colony formulation in AGS and SGC7901 cells treated with 10 μM cisplatin alone or in combination with 3 μM SOP were visualized by crystal violet staining. d Statistical analysis of colony numbers in AGS and SGC7901 cells. e-g Apoptosis in AGS and SGC7901 cells treated with 10 μM cisplatin alone or in combination with 3 μM SOP were determined by flowcytometry. Abbreviation: SOP, Sophoridine. The results are representatives of at least 3 independent experiments. Data were presented as mean ± SD. **P < 0.01; ***P < 0.0001; NS, no significant difference. Abbreviation: SOP, Sophoridine