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. 2020 Jun 12;31(11-12):664–678. doi: 10.1089/hum.2019.277

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© Karen Guerin et al., 2020; Published by Mary Ann Liebert, Inc.

This Open Access article is distributed under the terms of the Creative Commons Attribution Noncommercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and the source are cited.

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Figure 6. — Analysis of promiscuous recombination at Lox sites in Cre-dependent viruses. (A) Schematic outlining the premise of the recombination detection Python script and the relative percentage of recombination at Lox sites across samples. (B) Frequency of the percentage of Cre-independent recombination at LOX sites from 198 samples. (C) Cells were infected with AAV-FLEX-rev-ChR2(H134R)-mCherry (AAV9-18916) in the presence and absence of Cre, and mCherry expression was assessed by direct fluorescence. (D) Comparison of the rates of Cre-independent recombination between plasmid DNA and its associated viral DNA extracts. Color images are available online.