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. 2020 Jun 22;20:583. doi: 10.1186/s12885-020-07069-9

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — OTUD3 expression is decreased in breast cancer tissues. a Representative IHC staining images of OTUD3 in BC tissues and normal breast tissues. The magnifications of the upper and lower images are 100× and 200×, respectively. b OTUD3 staining was assessed, calculated, plotted and analyzed. **p < 0.01 (Chi-square test). c WB results of 12 pairs of fresh tissues samples. d OTUD3 expression was independent of the histological grade. e Positive correlations were identified among OTUD3, p53 and p21 expression in breast cancer tissues. C, breast cancer tissue; N, matched normal tissue