Table 4.
Blood parameters of chemotherapy cycles with short-term fasting or normocaloric diet comparing cycles of mSTF (n = 56) with cycles of NC (n = 62)
| Unit | NC | mSTF | PE ± SD | 95% CI | P-Value | |
|---|---|---|---|---|---|---|
| Blood count | ||||||
| Leukocytes | 103/μl | 6.67 ± 2.23 | 6.09 ± 2.25 | − 0.25 ± 0.30 | −0.84 – 0.35 | 0.406 |
| Thromobytes | 103/μl | 288.2 ± 76.6 | 306.6 ± 76.9 | 4.85 ± 10.76 | −16.56 – 26.25 | 0.654 |
| Erythrocytes | 103/μl | 3.91 ± 0.47 | 3.95 ± 0.37 | 0.11 ± 0.06 | −0.01 – 0.23 | 0.071 |
| Haemoglobin | g/dl | 11.7 ± 1.4 | 11.6 ± 1.1 | 0.18 ± 0.18 | −0.19 – 0.54 | 0.337 |
| Haematocrit | % | 33.5 ± 3.9 | 33.1 ± 2.9 | 0.31 ± 0.52 | −0.72 – 1.33 | 0.553 |
| MCH | pg | 29.9 ± 1.5 | 29.5 ± 1.6 | −0.38 ± 0.13 | −0.63 – (− 0.13) | 0.004 |
| MCV | 10− 9 μl | 85.7 ± 4.0 | 84.1 ± 3.7 | −1.68 ± 0.33 | −2.33 – (− 1.02) | < 0.001 |
| MCHC | g/dl | 34.9 ± 0.9 | 35.1 ± 0.9 | 0.23 ± 0.14 | − 0.05 – 0.51 | 0.109 |
| Neutrophils | 103/μl | 4.70 ± 2.20 | 4.29 ± 2.24 | −0.17 ± 0.30 | −0.76 – 0.43 | 0.581 |
| Lymphocytes | % | 21.0 ± 10.7 | 19.7 ± 12.4 | −0.89 ± 1.32 | − 3.50 – 1.73 | 0.503 |
| Monocytes | % | 8.22 ± 4.70 | 10.1 ± 5.3 | 0.90 ± 0.72 | −0.52 – 2.33 | 0.210 |
| Eosinophils | % | 0.71 ± 1.29 | 0.51 ± 1.18 | −0.05 ± 0.19 | −0.42 – 0.33 | 0.813 |
| Basophils | % | 0.68 ± 0.76 | 0.74 ± 0.59 | −0.02 ± 0.10 | −0.18 – 0.22 | 0.860 |
| Electrolytes | ||||||
| Potassium | mmol/l | 4.29 ± 0.42 | 4.28 ± 0.32 | −0.01 ± 0.07 | −0.15 – 0.12 | 0.845 |
| Sodium | mmol/l | 139.2 ± 2.2 | 137.9 ± 3.3 | − 1.17 ± 0.42 | − 2.0 – (− 0.33) | 0.007 |
| Calcium | mmol/l | 2.33 ± 0.14 | 2.34 ± 0.15 | 0.02 ± 0.03 | −0.04 – 0.07 | 0.561 |
| Magnesium | mmol/l | 0.80 ± 0.07 | 0.78 ± 0.07 | −0.0 ± 0.01 | −0.02 – 0.02 | 0.840 |
| Liver and kidney parameters | ||||||
| Urea | mg/dl | 26.9 ± 10.0 | 25.3 ± 10.6 | − 1.087 – 1.34 | −4.54 – 0.79 | 0.165 |
| Creatinine | mg/dl | 0.71 ± 0.16 | 0.72 ± 0.19 | 0.02 ± 0.01 | −0.01 – 0.05 | 0.171 |
| Uric acid | mg/dl | 4.44 ± 1.33 | 5.98 ± 1.79 | 1.35 ± 0.17 | 1.01–1.68 | < 0.001 |
| Bilirubin | mg/dl | 0.33 ± 0.25 | 0.29 ± 0.11 | 0.01 ± 0.03 | − 0.05 – 0.07 | 0.305 |
| GOT | U/l | 24.2 ± 8.7 | 25.0 ± 7.2 | 1.38 ± 1.48 | − 1.56 – 4.32 | 0.353 |
| GPT | U/l | 22.4 ± 11.8 | 23.5 ± 12.2 | −0.10 ± 1.46 | −3.01 – 2.81 | 0.947 |
| AP | g/dl | 71.4 ± 22.0 | 73.6 ± 25.0 | − 1.96 ± 2.29 | −6.52 – 2.58 | 0.392 |
| Albumin | g/dl | 4.31 ± 0.35 | 4.29 ± 0.32 | 0.02 ± 0.06 | − 0.09 – 0.13 | 0.741 |
| CRP | mg/l | 5.57 ± 4.93 | 8.1 ± 13.5 | 0.87 ± 1.95 | − 3.0 – 4.73 | 0.657 |
| Hormones | ||||||
| TSH | μU/ml | 1.05 ± 0.74 | 1.03 ± 0.73 | −0.1 ± 0.07 | −0.24 – 0.05 | 0.188 |
| fT3 | pmol/l | 4.21 ± 0.81 | 3.75 ± 0.76 | −0.47 ± 0.09 | −0.64 – (− 0.30) | < 0.001 |
| Ft4 | pmol/l | 15.5 ± 2.7 | 16.4 ± 2.9 | 0.82 ± 0.37 | 0.09–1.55 | 0.028 |
| Insulin | pmol/l | 252.7 ± 372.8 | 140.1 ± 252.4 | − 169.4 ± 44.1 | − 257.1 – (− 81.8) | < 0.001 |
| IGF-1 | ng/ml | 127.7 ± 55.7 | 97.8 ± 46.4 | − 33.3 ± 5.4 | −44.1 – (− 22.5) | < 0.001 |
Values are shown as mean ± SD. Due to missing data, we included data of 61 cycles of NC and 56 cycles of mSTF in this analysis. Abbreviations: AP alkaline phosphatase, CRP C-reactive protein, GOT glutamic-oxaloacetic transaminase, GPT glutamic-pyruvic transaminase, IGF-1 insulin-like growth factor 1, MCH mean corpuscular haemoglobin, MCHC mean corpuscular haemoglobin concentration, MCV mean corpuscular volume, fT3 free triiodothyronine, fT4 free thyroxine, TSH thyroid stimulating hormone