Table 2.
EP4R mRNA expression levels in three canine malignancies
| Tissuea | Median copy number/Cell | Median H-score | Median % probe positive |
|---|---|---|---|
| SCC | 3.1 (range: 0.2–10.0) | 69.51 (range: 6.001–167.2) | 32.45 (range: 3.485–59.54) |
| Skin | 0.5 (range: 0.1–3.3) | 15.56 (range: 5.071–56.80) | 9.67 (range: 4.812–24.01) |
| p-value | 0.0106* | 0.0078* | 0.0106* |
| AGASACA | 2.9 (range: 1.1–32.64) | 68.79 (range: 25.62–317.4) | 32.06 (range: 12.55–89.59) |
| Anal Sac | 1.5 (range: 0.2–4.8) | 34.76 (range: 8.439–103.4) | 18.28 (range: 7.118–56.19) |
| p-value | 0.0142* | 0.0188* | 0.0400* |
| TCC | 0.4 (range: 0.1–1.3) | 11.62 (range: 3.671–32.23) | 6.80 (range: 2.505–16.25) |
| Bladder | 5.1 (range: 0.7–9.8) | 80.00 (range: 23.06–139.6) | 30.78 (range: 13.84–52.19) |
| p-value | < 0.0001* | < 0.0001* | < 0.0001* |
SCC Squamous Cell Carcinoma, AGASACA Apocrine Gland Anal Sac Adenocarcinoma, TCC Transitional Cell Carcinoma
aNon-normally distributed data was evaluated with the Mann Whitney test between neoplastic cells and corresponding normal tissue type; the median and range are reported
*Statistically significant