Table 2.
Attribute Definitions in the Sample Component
| Attribute code | Attribute name | Allowed values | Attribute description | Constraints | Cardinality |
|---|---|---|---|---|---|
| MIABIS-SAMPLE-01 | Sample ID | Coded String | Unique ID of the sample within a sample collection, often represented by the sample barcode; text identifier. Sample ID meant for sharing | Pseudonymized, alphanumeric. It is recommended that sample IDs will be persistent within a given biobank | 1 |
| MIABIS-SAMPLE-02 | Detailed sample type | Amniotic fluid; Ascites fluid; Bile; Body cavity fluid; Bone; Bone marrow aspirate; Bone marrow plasma; Bone marrow, whole; Breast milk; Bronchoalveolar lavage; Buffy coat; Cancer cell lines; Cerebrospinal fluid; Cord blood; Dental pulp; Digital sample; DNA; Embryo; Entire body organ; Feces; Fetal tissue; Fibroblasts; Gas, exhaled ( = breath); Gastric fluid; Hair; Immortalized cell lines; Isolated microbes; Menstrual blood; Nail; Nasal washing; Pericardial fluid; PBMC; Placenta; Plasma; Pleural fluid; Primary cells; Postmortem tissue; Proteins; Red blood cells; RNA; Saliva; Semen; Serum; Sputum; Stem cells and iPS cells; Swab; Sweat; Synovial fluid; Tears; Teeth; Tissue (Frozen); Tissue (FFPE); Umbilical cord; Urine; Urine sediment; Vitreous fluid; Whole blood; Whole blood, dried (e.g., Guthrie cards) | The sample type saved from a biological entity for testing, diagnostic, propagation, treatment or research purposes | 1 | |
| MIABIS-SAMPLE-03 | Sample storage temperaturea | List: RT, 2°C to 10°C, −18°C to −35°C, −60°C to −85°C, < −135°C, Liquid nitrogen vapor phase, Liquid nitrogen liquid phase, Other | The long-term storage temperature at which the sample is stored after preparation, based on SPREC v3. | 0 | |
| MIABIS-SAMPLE-04 | Sample creation date and time | yyyy-mm-ddThh:mm:ss | The date and time the sample was created in the form currently described in MIABIS-SAMPLE-02 Detailed material type. Format according to ISO8601. Could also be partial, for example, YYYY. | 0 | |
| MIABIS-SAMPLE-05 | Anatomical site ontology | String | Name of ontology used for describing the anatomical source of the sample material, for example, ICD-O-3 topography code | MIABIS-SAMPLE-05 and MIABIS-SAMPLE-06 are required if any ontology information is provided | 0/1 |
| MIABIS-SAMPLE-06 | Anatomical site ontology version | Coded String | Version of selected ontology for anatomical site. | MIABIS-SAMPLE-05 and MIABIS-SAMPLE-06 are required if any ontology information is provided | 0/1 |
| MIABIS-SAMPLE-07 | Anatomical site ontology code | Coded String | Anatomical site code from the selected anatomical site ontology version | MIABIS-SAMPLE-05 and MIABIS-SAMPLE-06 are required if any ontology information is provided | 0 |
| MIABIS-SAMPLE-08 | Anatomical site ontology description | String | Description from the selected anatomical site ontology code | MIABIS-SAMPLE-05 and MIABIS-SAMPLE-06 are required if any ontology information is provided | 0 |
| MIABIS-SAMPLE-09 | Anatomical site free text | String | Explanation about Anatomical site in case of unknown Anatomical site or insufficient information | MIABIS-SAMPLE-05 and MIABIS-SAMPLE-06 are required if any ontology information is provided | 0 |
| MIABIS-SAMPLE-10 | Sample content diagnosis | List: Healthy, [ICD-10 code], Unknown, Not applicable | The ICD-10 diagnosis code describing content of the sample, such as whether the sample contains cancerous material | 0 … n | |
| MIABIS-SAMPLE-11 | Use restrictions | List: Commercial use restriction, DNA use restriction, Outside EU access restriction, Xenograft restriction, Other animal work restriction, Other restriction | The restrictions that may change the availability of the samples donated by the sample donor (see Supplementary Table S1. “Example on how to tabulate list-attributes for database use” for coded list items). | 0 … n |
a
See additional discussion in Synchronization with MIABIS Core section.
EU, European Union; FFPE, formalin-fixed, paraffin embedded; PBMC, peripheral blood mononuclear cells; RT, room temperature; SPREC, Sample PREanalytical Code.