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. Author manuscript; available in PMC: 2020 Jun 23.
Published in final edited form as: Neurobiol Learn Mem. 2018 Nov 5;156:103–116. doi: 10.1016/j.nlm.2018.11.002

Fig. 3.

Fig. 3.

(A&C) In the object placement task, control mice administered 2 mg/kg CNO immediately post-training spent significantly more time than chance (15 s) with the moved object 4 h after training, whereas DH-hM4Di-expressing mice administered 2 mg/kg CNO did not. (B) In the object recognition task, control and DH-hM4Di mice administered 2 mg/kg (D), 4 mg/kg (E), or 8 mg/kg (F) CNO immediately post-training all spent significantly more time than chance (15 s) with the novel object during testing, suggesting intact object recognition memory 24 h after training. This finding suggests that post-training hM4Di-mediated inactivation of the DH impairs spatial memory consolidation, but does not affect object recognition memory consolidation, even at escalating doses of CNO. Bars represent the mean ± SEM, *p < 0.05 relative to chance or the Control group.