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. Author manuscript; available in PMC: 2020 Jun 23.
Published in final edited form as: Neurobiol Learn Mem. 2018 Nov 5;156:103–116. doi: 10.1016/j.nlm.2018.11.002

Fig. 6.

Fig. 6.

Experimental design for the object placement (A) and object recognition task (B). DREADD-mediated inhibition of the mPFC impaired both object placement (C) and object recognition (D) memory in mice expressing hM4Di in the mPFC that were administered 2 mg/kg CNO immediately after training, but not in control mice. A 1 mg/kg dose of CNO did not impair memory in the object placement (E) or the object recognition (F) task in control or hM4Di groups. These findings suggest that hM4Di-mediated inactivation of the mPFC in combination with 2 mg/kg CNO impairs spatial and object recognition memory consolidation. Bars represent the mean ± SEM, *p < 0.05 relative to chance or the Control group.